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Cellular and integrative functions of purines

Cellular & Integrative Neuroscience Cellular & Integrative Neuroscience

Organised by Bruno Frenguelli and Mark Wall, University of Warwick, UK

Thursday 14 July 2011
LT3 (Large lecture theatre Sherrington Building)

The purines adenosine and ATP regulate a myriad of physiological processes in the mammalian CNS. These actions are mediated through a range of ionotropic and G-protein coupled receptors which are expressed at high density by neurones and glia. Moreover, it has been established that ATP is a gliotransmitter capable of influencing synaptic activity both directly, following vesicular release, and indirectly, after metabolism to adenosine. This session highlights some recent discoveries concerning the influence of purines in neuronal function, from regulating adult neurogenesis, to modulating synaptic plasticity through interactions with BDNF signalling, to underpinning nociception. In addition, recent findings on the properties of ATP-mediated neuro-glia communication will be described, as will the importance of astrocytic purinergic signalling in the control of autonomic function. Delivered by experts in their respective fields, the talks in this Symposium will serve both as a state-of-the-art commentary for the cognoscenti, as well as a primer for the neuro-glia and purine curious.

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08.45 Welcome and introduction by the organisers
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A role for purinergic signalling in adult neurogenesis

  Herbert Zimmermann, Goethe-Universität, Frankfurt, Germany
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Modulation of hippocampal synaptic plasticity by adenosine A2A receptors

  Ana Maria Sebastião, University of Lisbon, Portugal
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Painful P2X3 receptors

  Peter Illes, Universität Leipzig, Germany
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10.30 Refreshments
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Role for ATP receptors in glia-neuron communication

  Yuriy Pankratov, University of Warwick, UK
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Using optogenetics to study astrocytic purinergic signalling in the brainstem

  Sergey Kasparov, University of Bristol, UK
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Physiology 2011
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