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Intracellular calcium and cardiac arrhythmias

Cardiac & Respiratory Physiology Cardiac & Respiratory Physiology

Organised by David Eisner and Luigi Venetucci, University of Manchester, UK

Thursday 14 July 2011
LT1 (University Museum of Natural History)

Much work in recent years has pointed to clear links between alterations in cardiac cellular calcium and the development of cardiac arrhythmias. Such disordered calcium signalling can be induced pharmacologically even in normal cells. However, these Ca-dependent arrhythmias are particularly evident in two clinical situations. (1) Heart failure; (2) in some inherited arrhythmias which result from mutations in genes encoding various calcium handling proteins. This translational symposium will move from the basic mechanisms underlying abnormal calcium signalling through to the disease situation.

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08.45 Welcome and introduction by the organisers
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Critical factors controlling spontaneous SR Ca release in isolated ventricular cardiomyocytes

  Godfrey Smith, University of Glasgow, UK
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Role of CaMKII in hypertrophy and heart failure

  Lars Maier, Georg-August-Universitaet Göttingen, Germany
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Ca handling in persistent atrial fibrillation

  Karin Sipido, Katholieke Universiteit, Leuven, Belgium
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10.30 Refreshments
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Cardiac electrical remodeling in arrhythmogenesis

  David Rosenbaum, Case Western Reserve University, Cleveland, USA
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Calcium handling abnormalities in inherited arrhythmias

  Silvia Priori, Fondazione Salvatore Maugeri, Pavia, Italy
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