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Vascular control by the extracellular matrix

Vascular & Smooth Muscle Physiology Vascular & Smooth Muscle Physiology

Organised by Ulrich Pohl, Ludwig-Maximilians-Universität, Munich, Germany

Wednesday 13 July 2011
LT4 (Pharmacology lecture theatre)

In recent years, evidence has accumulated, that the extracellular matrix proteins in the vascular basement membrane decisively affect the vascular function in particular as it is related to endothelial cells. This is not only achieved by alterations of the matrix composition but also by its dynamic processing. Various signalling pathways are stimulated by the release and activation of matrix degrading enzymes, resulting in generation of new signalling sequences (matricryptins) leading to specific integrin activation. The matrix derived signals play an important role not only in physiologic adaptation of vessel calibres (e.g. in response to chronic exercise) but also in pathophysiologic processes such as remodelling of the microvasculature in diabetes or hypertension. As examples, the role of specific matrix proteins as well as basic mechanisms of matrix control of vascular tone, growth and cellular function/differentiation will be highlighted in the symposium.

Physiology 2011
Physiology 2011
08.45 Welcome and introduction by the organiser
Physiology 2011
09.00
x

Vascular extracellular matrix proteins controlling endothelial and smooth muscle function

  Madeleine Durbeej-Hjalt, Lund University, Sweden
Physiology 2011
09.30x

Insights from proteomic analyses of adhesion signalling

  Martin Humphries, University of Manchester, UK
Physiology 2011
10.00
x

Integrins and matricryptins in the control of microvascular tone and structural adaptation

  Gerald Meininger, University of Missouri, Columbia, USA
Physiology 2011
10.30 Refreshments
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11.15
x

Control of shear stress induced endothelial growth factor release by extracellular matrix proteins

  Ulrich Pohl, Ludwig-Maximilians-Universität, Munich, Germany
Physiology 2011
11.45

A proangiogenic role of the vascular basement membrane

  Luca Primo, University of Torino, Italy
Physiology 2011

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