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Programme overview Plenary Lectures Symposia Public Lecture Young Physiologists' Symp
Smooth muscle and endothelial cell signaling microdomains: Implications for vascular function

Vascular & Smooth Muscle Physiology Vascular & Smooth Muscle Physiology

Organised by Ron Lynch, University of Arizona, Tucson, USA
and Christopher Garland, University of Oxford, UK

Tuesday 12 July 2011
LT2 (Experimental Psychology A)

This symposium will present recent research attempting to define and link cellular signalling microdomains to the integration of physiological function in the vasculature.

Topics to be addressed will focus on calcium and cAMP signalling, and include novel pathways involving acid-sensitive stores, the role of membrane rafts and caveolae in focusing cell signaling proteins, signalling microdomains in vascular endothelial and smooth muscle cells and the regulation of, in particular, TRP and potassium channels and Na/K ATPases.

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08.45 Welcome and introduction by the organisers
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NAADP-mediated local calcium signaling via endolysosomal two-pore channels

  Anthony Galione, University of Oxford, UK
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Caveolins in cardiovascular cells: SUMOylation as a novel regulator

  Paul Insel, University of California, San Diego, USA
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Local calcium signalling through TRPV4 channels and IP3Rs in the vascular endothelium

  Mark Nelson, University of Vermont, USA
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10.30 Refreshments
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Endothelial cell microdomains and integrated vascular dilatation

  Kim Dora, University of Oxford, UK
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Organization of calcium signaling pathways: Coupling of active Na+ transport, calcium signaling and glycolysis in cells of the vasculature

  Ron Lynch, University of Arizona, Tucson, USA
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Sponsored by DMT


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