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Physiology 2011

Proton signals and sensors
Physiology 2011

Metabolism & Endocrinology Metabolism & Endocrinology

Organised by Richard Vaughan-Jones, University of Oxford, UK

Tuesday 12 July 2011
Lecture theatre to be confirmed

Protons (H+-ions) are universal products of metabolism that powerfully modulate cell proliferation, development,and regulatory function. This symposium addresses the emerging molecular mechanisms for H+- ion sensing and signalling in cells. Novel mechanisms include H+-activated G-protein coupled receptors, specific ion channels & transporters, and pH- transducing enzymes, all of which co-ordinate primary cell function in a highly evolved and sophisticated manner. The symposium will highlight major developments in our understanding of this fundamental signalling system.

Physiology 2011
Physiology 2011
08.45 Welcome and introduction by the organiser
Physiology 2011
09.00

Acid sensitive ion channels: From molecular properties to physiopathology

  Michel Lazdunski, Université Nice Sophia Antipolis, France
Physiology 2011
09.30

G-protein coupled proton receptors: Expression, characterisation & function

  Klaus Seuwen, Novartis Institutes for BioMedical Research, Basel, Switzerland
Physiology 2011
10.00
x

Role of CA9 in the control of intracellular and extracellular pH in 3-dimensional tumour-cell growths

  Pawel Swietach, University of Oxford, UK
Physiology 2011
10.30 Refreshments
Physiology 2011
11.15

H+ sensing and translocation by the voltage-gated proton channel

  Mark Sansom, University of Oxford, UK
Physiology 2011
11.45
x

H+-coupled Ca2+ signaling in heart: role of Na-H exchange, mitochondria, and the L-type Ca2+ channel

  Richard Vaughan-Jones, University of Oxford, UK
Physiology 2011
Physiology 2011
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